Table 4.
Association between rs833061 −460C>T variants and lung cancer survival.
| Trials | N | SNP variant | Reference genotype (No.) | Survival | Variant genotype (No.) | Survival | HR (95% CI) | P | Variant genotype (No.) | Survival | HR (95% CI) | P |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Heist et a. 2008 | 462 | −460T/C | TT (145) | *57 (47–65) | CC (112) | *52 (41–61) | 1.25 (0.89–1.77) | 0.20 | TC (205) | *61 (53–67) | 0.99 (0.73 to 1.36) | 0.98 |
| Guan et al. 2010 | 124 | −460T/C | TT (33) | †16.0 (11.0–25.0) | CC (24) | †27.0 (10.0–36.0) | 0.67 (0.36–1.26) | 0.212 | CC+CT (91) | †21.0 (17.0–31.0) | 0.58 (0.37–0.92) | 0.022 |
| Masago et al. 2009 | 126 | −460T/C | CT+TT (115) | ‡643 (342–801) | CC (11) | ‡257 (125, 351) | 1.719 (1.166–2.390) | 0.0084 | – | – | – | – |
| de Mello et al. 2013 | 144 | −460T/C | CC (28) | †9 (5.38–12.61) | CT (79) | †11 (8.47–13.52) | 1.028 (0.331–3.196) | 0.036 | CT+TT (116) | †10 (8.14–11.86) | 1.011 (0.336–3.039) | 0.011 |
*
5-Year OS (%)(95% CI);
†
Median Survival Time (month)(95% CI);
‡
Median Survival Time (day) (95% CI);
HR – hazard ratio; CI – confidence interval; Bold was used for highlight statistical significance.