Basal hydrogen peroxide generation was measured in freshly isolated bone marrow cells from 6 wk female C57Bl6 mice (n=3), plated in quadruplicate, and treated with either 200 nM GEN or 1 nM E2 at 37°C for an hour, using the Amplex Red hydrogen peroxide/peroxidase assay kit as described in Materials and Methods. Data expressed as the amount produced (μM). Statistical significance was determined by a two-tailed Student’s T-test for every time point, *p<0.05 control vs. E2, **p<0.05 control vs. GEN.