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. 2014 Dec 15;25(25):4106–4114. doi: 10.1091/mbc.E14-08-1255

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© 2014 Shi et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 9: — Schematic mechanism by which Olfm2 regulates SM marker gene transcription. On TGF-β stimulation, Olfm2 is induced by Smad2/3 and then translocated into nuclei of progenitor cells, where it binds to SRF, causing SRF dissociation from HERP1. Olfm2 then facilitates and even promotes SRF binding to CArG box in the SM gene promoter, resulting in increased transcriptional activation of SM markers.