TABLE 1:

Muscle strength, locomotor activity, and limb coordination of adult Pax7-Cre/cKO mice.

Test	Parameter	wt	Pax7-Cre/cKO
Grip strengtha	FLs (g/g)	5.0 ± 0.2	2.6 ± 0.1***
	Total (g/g)	8.3 ± 0.5	4.3 ± 0.2***
Open fieldb	Global distance (m)	77.7 ± 4.2	50.1 ± 28.5***
	Rearing time (min)	12.4 ± 1.5	6.9 ± 0.4***
	Time spent in peripheral sector (%)	66.8 ± 2.7	67.7 ± 3.6
	Time spent in central sector (%)	33.8 ± 2.0	33.5 ± 2.3
Rotarodc	Latency of falling (s, day 1)	35.0 ± 2.0	19.1 ± 3.4*
	Latency of falling (s, day 2)	69.7 ± 14.1	40.3 ± 3.5*
	Latency of falling (s, day 3)	92.6 ± 8.3	64.2 ± 1.7

^aGrip strength of FLs and of FLs and HLs combined (total) of mutant compared with wt mice assessed using a grip strength meter; measurements were normalized to body weight; mice analyzed: wt, 15; Pax7-Cre/cKO, 8. Mean ± SEM.

^bGeneral locomotor activity (during 30 min) was assessed in open field test; mice analyzed: wt, 28; Pax7-Cre/cKO, 26. Mean ± SEM.

^cTo analyze body balance, the time mice abided on a rotating rod was measured; mice analyzed: wt,12; Pax7-Cre/cKO, 11. Mean ± SEM.

*p < 0.05, ***p < 0.001, unpaired Student's t-test.