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. 2014 Dec 11;10(12):e1004865. doi: 10.1371/journal.pgen.1004865

Figure 2. MSL recruitment to the conserved HAS is independent of roX.

Figure 2

(A) MOF and MSL1 ChIP-seq enrichment profiles, with a 500 bp smoothing, for a representative region of the X-chromosome in salivary gland tissue from wild type and roX mutant males. Numbers along the x-axis denote positions along the chromosome in kb. The y-axis shows the ChIP enrichment over input as log2 ratios. Genes expressed from left to right and vice versa are shown above and below the horizontal lines, respectively. The HAS locations, previously defined by [34], [37], [38], are indicated by grey boxes. (B) Fraction of sites on the X-chromosome from roX mutants that are bound by MSL1, compared to random sites along the X-chromosome (red), sorted by distance to HAS. (C) MSL1 ChIP-seq enrichment profile, with a 500 bp smoothing, for the entirety of chromosomes X and 2L in salivary glands from D. simulans wild type males. Numbers along the x-axis denote chromosomal positions in Mb. The y-axis shows the ChIP enrichment over input as log2 ratios. (D) Sequence motifs enriched in MSL-bound regions of the X-chromosome in D. melanogaster wild type [37], roX mutants and D. simulans wild type.