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. Author manuscript; available in PMC: 2014 Dec 11.
Published in final edited form as: J Mol Cell Cardiol. 2010 Jul 15;49(4):699–706. doi: 10.1016/j.yjmcc.2010.07.005

Fig. 2.

Fig. 2

Echocardiographic assessment of RV diastolic dysfunction in rVSD. (a), Pulsed-wave Doppler echocardiography from a control and 6-week rVSD animal demonstrates inversion of the tricuspid valve early (E) and late (A)diastolic in flow velocity ratio (E/Aratio) in rVSD. A tricuspid valve E/A ratio < 1.0 was used to define RV diastolic dysfunction (and study termination). The mitral valve E/A ratio remained unchanged in rVSD compared to controls. (b), Progressive decline in the tricuspid valve E/A ratio over time in rVSD animals (n = 3). The baseline column is combined from controls (n = 5) and baseline rVSD (n = 3) data.