Table 3.

Altered RV isolated myocyte contractile and relaxation in rVSD. Isolated myocyte functional studies were performed on RV myocytes from control and rVSD animals immediately following heart harvest to assess contraction/relaxation parameters. Data are presented as the mean ± SEM from 4 myocytes per animal (n = 5 control and n = 3 rVSD pigs). Data was analyzed using a two-tailed unpaired t test with p < 0.05 considered significant.

Parameters	Control (n = 20 cells)	rVSD (n = 12 cells)	p
Baseline sarcomere length, µ	2.68 ± 0.2	2.14 ± 0.03	0.05
Contraction parameters
Departure velocity, mm/s	−2.50 ± 0.33	−1.23 ± 0.3	0.01
Departure velocity time, s	0.071 ± 0.007	0.11 ± 0.02	0.03
Peak, mm	2.41 ± 0.2	1.99 ± 0.02	0.09
Peak height, mm	0.26 ± 0.03	0.15 ± 0.03	0.01
Baseline% peak height,%	10.2 ± 0.9	6.98 ± 1.3	0.04
Peak time, s	0.33 ± 0.02	0.49 ± 0.03	0.0004
Time to peak 50%, s	0.10 ± 0.007	0.16 ± 0.03	0.008
Time to peak 90%, s	0.21 ± 0.01	0.33 ± 0.04	0.001
Relaxation parameters
Return velocity, mm/s	2.85 ± 0.42	1.44 ± 0.42	0.03
Return velocity time, s	0.45 ± 0.04	0.73 ± 0.06	0.0002
Time to baseline 50%, s	0.46 ± 0.04	0.73 ± 0.05	0.0001
Time to baseline 90%, s	0.55 ± 0.04	0.82 ± 0.06	0.0003