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. 2014 Sep 25;3(6):897–909. doi: 10.1002/mbo3.214

Figure 7.

Figure 7

Impact of mutating individual protease genes/operons in vivo. Mice were infected by tail vein injection of LAC, FPR3757, their isogenic sarA mutants (S), or sarA mutants unable to produce the indicated proteases, with SP indicating a LAC sarA mutant unable to produce any extracellular protease. The ssp mutant used in these studies is the sspA polar mutant unable to produce SspA or SspB. Results shown are weight gain/loss or colony counts in the indicated tissues. Boxes indicate the 25th and 75th percentiles for each group and define the interquartile range (IQR), with the horizontal line indicating the median. Vertical lines define the lowest and highest data points within 1.5 IQR of the lower and higher quartile, respectively, with individual dots representing single data points outside this range. The light gray boxes represent the USA300 strain LAC. The dark gray boxes represent the USA300 strain FPR3757. Single asterisk indicates statistical significance of the sarA mutant by comparison to the appropriate parent strain. Double asterisks indicate statistical significance of the sarA mutant by comparison to the isogenic protease-deficient sarA mutant.