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. 2012 Apr 25;2(2):127–170. doi: 10.3390/bios2020127

Figure 19.

Figure 19

ECAR of HEK293 cells under stimulation of BK. (a) ECAR measurements were monitored. BK (white circles) stimulates ECAR, whereas the BK B1 receptor agonist des-Agr9-BK (dark circles) does not. Cells were exposed to perfusate-containing drug during the time span encompassed by the gray box; (b) ECAR stimulated by 10−6 M of BK in various buffers, including Ham’s F12 medium, without and with 10−5 M MIA, a balanced salt solution containing NaCl or TMA substituted mM per mM for sodium. * P < 0.05 vs. BK alone; zP < 0.01 vs. BK in balanced salt solution with NaCl; (c) Effects of BK B2 (HOE-140) and BK B1 (des-Arg10-HOE-140) receptor antagonists on BK-stimulated ECAR. Antagonists (10−5 M) were added 30 min prior to addition of BK. All experiments were performed at least 4 times. zP < 0.01 vs. BK alone. Error bars in (b) and (c) represent the S.E.M. (Reprinted from [115]. © 2009, with permission from Elsevier).