Figure 10a:

Images in a 65-year-old man with right upper lobe adenocarcinoma, with tracer transport rate constant (k_ep) of 3.2 min⁻¹. (a) Axial T2-weighted half-Fourier acquisition single-shot turbo spin-echo MR image (pulse repetition time msec/echo time msec = 1200/100; field of view [FOV] = 400 mm; 320 × 320; one signal acquired; bandwidth [BW] = 780 kHz; flip angle [FA] = 150°; echo train length [ETL] = 256; 5.5-mm section thickness, 1.6-mm intersection gap; acquisition time = 6 min) and (b) postcontrast (gadopentetate dimeglumine 0.1 mmol/kg bolus injection) sagittal T1-weighted volumetric interpolated breath-hold examination MR image (3.4/1.3; FOV = 400 mm; 260 × 320; one signal acquired; BW = 505 kHz; FA = 10°; 4-mm section thickness, 0-mm intersection gap; acquisition time = 1.7 min) demonstrate right upper lobe lesion representing adenocarcinoma. (c) Representative parametric maps of tumor area on T1-weighted MR image (500/1.6, FOV = 400 mm, 192 × 180, one signal acquired, BW = 360 kHz, FA = 10°, 5-mm section thickness, oblique sagittal orientation, 124 frames, 2 seconds per frame, acquisition time = 4 min, gadopentetate dimeglumine 0.1 mmol/kg intravenously). Left panel: Goodness-of-fit map color-coded according to confidence level of χ² test overlaid on T1-weighted image. Middle panel: Boundaries of voxels with more than 50% confidence level of χ² test are superimposed on T1-weighted image. Right panel: Color-coded k_ep map. The map shows k_ep values of the entire tumor area. The k_ep values within the boundaries of the middle panel were used for the evaluation. The isolated voxel at the edge of the tumor is a single voxel. (Reprinted, with permission, from reference 75.)