Figure 4a:

Images in a 70-year-old woman with stage IV adenocarcinoma harboring EML4-ALK (anaplastic lymphoma kinase) translocation treated with ALK inhibitor crizotinib. (a) Coronal reformatted image from baseline chest CT demonstrates multiple nodules in the right lung (arrows) with nodular thickening of the right apical pleura (arrowheads), representing significant tumor burden. (b) The patient was treated with crizotinib. After 4 months of therapy, follow-up chest CT scan demonstrates marked decrease of the right lung nodules (arrows) and resolution of pleural tumor burden in the right apex (arrowheads).