Figure 5:

Genomic subtypes of NSCLC. The pie chart represents the subdivisions of lung adenocarcinomas based on different driver mutations detected from the testing of 516 tumors (114,115). KRAS = V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; EML4 = echinoderm microtubule-associated protein-like 4; ALK = anaplastic lymphoma kinase; BRAF = v-Raf murine sarcoma viral oncogene homolog B1; PI3KCA = phosphatidylinositol 3-kinase; HER2 = human epidermal growth factor receptor 2; MET = mesenchymal-epithelial transition factor; AMP = amplification; MEK1 = dual specificity mitogen-activated protein kinase kinase 1 (MAP2 K1); NRAS = neuroblastoma RAS viral (v-ras) oncogene homolog; AKT1 = V-akt murine thymoma viral oncogene homolog 1.