Trends between tumor volume and OS in the BRAIN trial for conventional segmentation (A, C, E) and CE T1-weighted subtraction maps (B, D, F). A, Trends in pretreatment tumor volume for conventional segmentation. B, Trends in pretreatment tumor volume for CE T1-weighted subtraction maps. C, Trends in posttreatment tumor volume for conventional segmentation. D, Trends in posttreatment tumor volume for CE T1-weighted subtraction maps. Tumor volume was measured in cubic centimeters (cc). E, Trends in volume change after therapy for conventional segmentation. F, Trends in volume change after therapy for CE T1-weighted subtraction maps.