Figure 5:

High- and low-risk patient stratification for the BRAIN trial with conventional segmentation or CE T1-weighted subtraction (CE-ΔT1w) maps. Patient cohorts were identified from single-stratification thresholds found in UCLA single-institution exploratory data (ie, pretreatment volume of 15 cm³ [cc], posttreatment volume of 7.5 cm³, and decrease in volume of 25%). A, PFS for high- and low-risk patients using pretreatment tumor volumes. B, PFS for high- and low-risk patients using posttreatment tumor volume estimates. C, PFS for high- and low-risk patients stratified on the basis of change in tumor volume as a result of therapy. D, OS for high- and low-risk patients by using pretreatment tumor volumes. E, OS for high- and low-risk patients by using posttreatment tumor volume estimates. F, OS for patients stratified on the basis of change in tumor volume after therapy.