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. 2014 Dec 11;9(12):e114441. doi: 10.1371/journal.pone.0114441

Table 4. Univariate and multivariate generalized estimating equations model of factors associated with HIV-1 viral loads.

Univariate Multivariate model I Multivariate model IIa
No. difference p difference p difference P
Gender
Male 603
Female 38 −26767.8 <0.001 −20826.2 0.013 −26658.9 <0.001
Age (yrs)
<30 286
30–50 290 −4936.2 0.449 1520.8 0.823 −3313.5 0.633
≥50 48 −4747.7 0.627 2665.1 0.802 8246.7 0.404
Mode of transmission
Homosexual contact 371
Heterosexual contact 70 −3605.2 0.706 10465.9 0.387 - -
Injecting drug use 128 −22329.5 <0.001 −73432.1 <0.001 - -
Receipt of blood products 6 −7205.5 0.752 −35456.4 0.227 - -
HIV-1 subtype
B 217
C 3 1607.7 0.940 23058.5 0.269 19596.9 0.325
CRF01_AE 16 −10620.5 0.291 −43785.9 0.004 −37612.3 0.004
CRF07_BC 30 −21153.8 0.005 −9074.4 0.472 −58045.6 <0.001
CRF08_BC 1 −7883.3 0.086 −113409.7 <0.001 −106777.7 <0.001
CD4 cell count (cells/mm3)
≤50 22
51–250 82 −263241.1 <0.001 −240696.2 <0.001 −246030.4 <0.001
251–500 209 −313911.1 <0.001 −290801.3 <0.001 −296881.6 <0.001
>500 160 −334294.9 <0.001 −300993.4 <0.001 −309618.0 <0.001
Received ART
No 270
Yes 371 −97661.2 <0.001 −102574.2 <0.001 −88088.5 <0.001
a

The mode of transmission was removed from multivariate model II.