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. 2014 Dec 11;9(12):e114970. doi: 10.1371/journal.pone.0114970

Table 1. Characteristics of study population by urinary albumin excretion status.

Normal urinary albumin excretion Low-grade albuminuria Increased urinary albumin excretion P for trend
n (%) 6795 (70.0) 2267 (23.4) 640 (6.6)
Urinary albumin to creatinine ratio (mg/g) 6.65 (5.02–8.40) 14.71 (12.53–18.99)* 53.13 (37.8–94.5)* <0.0001
GGT (U/L) 19 (14–28) 21 (15–30)* 24 (16–35)* <0.0001
Age (years) 55.5±7.7 56.7±8.4* 58.0±9.6* <0.0001
Male [n (%)] 2097 (30.9) 501 (22.1) 190 (29.7) <0.0001
BMI (kg/m2) 23.4±3.2 24.0±3.8* 24.7±3.7* <0.0001
WC (cm) 81.1±9.2 82.3±9.9* 85.1±10.4* <0.0001
SBP (mmHg) 124.2±15.6 128.9±16.8* 134.9±18.9* <0.0001
DBP (mmHg) 74.6±9.5 76.4±10.4* 78.8±11.0* <0.0001
Current smoker [n (%)] 702 (10.6) 163 (7.4) 74 (11.8) 0.070
Current drinker [n (%)] 227 (3.5) 67 (3.1) 23 (3.7) 0.777
TG (mg/dL) 108.85 (80.53–157.52) 115.93 (83.19–170.80)* 138.05 (97.35–194.69)* <0.0001
TC (mg/dL) 200.39±46.72 204.25±47.88* 203.09±52.12 0.002
HDL-C (mg/dL) 51.35±13.90 51.35±13.51 47.88±12.74* <0.0001
LDL-C (mg/dL) 121.24±35.91 122.78±37.45 122.78±38.61 0.083
FPG (mg/dL) 97.30 (90.09–105.95) 98.92 (90.81–109.00)* 100.72 (92.07–120.90)* <0.0001
HbA1C (%) 5.95±0.73 6.17±1.05* 6.55±1.53* <0.0001
HOMA-IR 1.67 (1.19–2.40) 1.88 (1.29–2.80)* 2.23 (1.45–3.48)* <0.0001
eGFR (ml/min per 1.73 m2) 112.9±22.0 113.5±23.9 108.6±31.9* 0.006
Physical activity (MET-h/week) 21.0 (10.5–45.0) 21.0 (10.5–42.0) 21.5 (10.5–42.0) 0.758

1. Data were means ± SD or medians (interquartile ranges) for skewed variables or numbers (proportions) for categorical variables.

2. P for trend was calculated for the linear regression analysis tests across the groups. P values were for the ANOVA or χ2 analyses across the groups.

3. *P<0.05 compared with normal urinary albumin excretion group.

4. BMI, body mass index; WC, waist circumference; SBP, systolic blood pressure; DBP, diastolic blood pressure; TG, triglycerides; TC, total cholesterol; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; FPG, fasting plasma glucose; HOMA-IR, homeostasis model assessment of insulin resistance; eGFR, estimated glomerular filtration rate; GGT, γ-glutamyltransferase.