Table 1. Proportion of cytokine producing CD4+, CD8+ and DN T cell subsets in various organs from vehicle- and Ang II-infused mice.
IFN-γ | TNF-α | IL-4 | IL-17 | ||||||
Vehicle | Ang II | Vehicle | Ang II | Vehicle | Ang II | Vehicle | Ang II | ||
Blood | CD4 | 2.0±0.3 | 1.7±0.2 | 14.6±2.8 | 16.5±2.7 | 0.5±0.1 | 0.4±0.1 | 0.7±0.2 | 1.1±0.2 |
CD8 | 5.5±1.0 | 7.0 ±12 | 9.6±2.5 | 6.8±1.7 | 0.4±0.1 | 0.8±0.2 | 0.4±0.1 | 0.5±0.1 | |
DN | 7.2 ±1.1 | 12.3 ±2.5 | 12.0±3.6 | 9.5±2.5 | 2.7±0.8 | 3.1±0.8 | 7.3±1.2 | 9.3±1.1 | |
Spleen | CD4 | 3.2 ±0.6 | 3.4 ±0.3 | 20.3±3.7 | 21.3±3.8 | 1.6±0.1 | 0.6±0.2 | 0.6±0.1 | 0.7±0.2 |
CD8 | 5.6 ±1.4 | 8.23±1.5 | 13.3±3.2 | 9.5±2.7 | 1.1±0.3 | 0.9±0.2 | 0.5±0.2 | 0.5±0.2 | |
DN | 13.4 ±2.8 | 18.1 ±3.0 | 7.1±1.3 | 8.8±1.3 | 3.1±0.9 | 2.9±0.6 | 4.1±0.5 | 3.2±0.4 | |
Aorta | CD4 | 7.4±1.5 | 6.1±1.4 | 8.7±2.3 | 12.9±2.8 | 0.7±0.2 | 1.2±0.4 | 0.8±0.3 | 1.1±0.3 |
CD8 | 2.8±0.6 | 5.0±0.7 * | 2.9±0.6 | 5.0±1.1 | 3.0±0.8 | 3.8±1.0 | 1.1±0.4 | 1.7±0.4 | |
DN | 3.4±0.9 | 4.1±1.0 | 5.2±1.2 | 6.1±1.4 | 2.5±1.0 | 4.7±1.7 | 5.9±1.7 | 4.2±0.7 | |
Kidney | CD4 | 5.7±2.2 | 9.9±2.6 | 3.6±0.7 | 3.7±1.1 | 2.0±0.5 | 1.7±0.5 | 1.7±0.3 | 1.5±0.4 |
CD8 | 2.7±1.0 | 2.6±0.7 | 5.6±1.5 | 4.1±1.0 | 3.4±0.7 | 2.8±0.7 | 0.5±0.2 | 1.5±0.6 | |
DN | 4.5±1.5 | 8.2±1.8 * | 3.2±0.6 | 6.1±3.5 | 0.7±0.2 | 1.7±0.5 | 4.7±1.2 | 3.7±0.7 | |
Brain | CD4 | 9.0±2.2 | 8.9±2.2 | 21.7±3.3 | 28.4±4.5 | 0.9±0.3 | 0.7±0.3 | 0.4±0.2 | 0.7±0.3 |
CD8 | 11.7±3.1 | 11.4±2.3 | 16.4±3.7 | 13.7±2.6 | 1.2±0.4 | 2.9±0.8 | 1.9±0.6 | 2.3±0.7 | |
DN | 9.5±2.7 | 14.4±3.2 | 12.7±3.8 | 7.4±2.4 | 2.7±1.5 | 5.4±1.9 | 8.7±3.4 | 8.1±3.7 |
*P<0.05 Vs Vehicle, Unpaired t –test, n = 11–19.