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. 2014 Dec 11;9(12):e114912. doi: 10.1371/journal.pone.0114912

Figure 2. The mutation spectra emerging from Peruvian HCCs display age-based peculiar genetic features.

Figure 2

(A) Mutations found in HCCs from <40 (left) and ≥40 (right) Peruvian patients, as see in CTNNB1, AXIN1, TP53, K-RAS, H-RAS, NFE2L2, and ARID2 genes (n = 80). Mutation presence is indicated on the upper panel by both blue and red check marks. Red check marks correspond to inactivating mutations, i.e. nonsense or frame shift mutations. Corresponding clinico-pathological features are mentioned on the lower panel. Check marks correspond to (from top to bottom): male sex; HBsAg(+); serum AFP level above the median; poorly differentiated tumor; ≥17 cm-diameter tumor; multinodular tumor; recurrence within 12 months following anatomic liver resection; metastatic cancer; and cirrhotic NTL. Red asterisks indicate significant differences between <40 and ≥40 patients both for HBsAg(+) (P<0.0001) and serum AFP level (P = 0.0006). Green asterisk indicates significant difference between HCCs with mutation(s) and HCCs with no mutation (P = 0.038). (B) Mutation spectrum of Peruvian HCC (n = 80). X-axis displays percentage of genetic alteration; y-axis displays each of the six classes of base substitution and Insertions/Deletions (InDels). (C) Bar chart illustrating the association between AXIN1 gene mutation and MDM2 GG genotype at the rs2279744 allele. (B,C) Error bars represent the standard errors of the counts.