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. 2014 Dec 11;9(12):e114623. doi: 10.1371/journal.pone.0114623

Figure 4. Effects of A-803467, a selective blocker of Nav1.8, on bone cancer-induced mechanical allodynia and thermal hyperalgesia in rats.

Figure 4

(A, B): Effects of A-803467 (at 50, 100 and 150 nmol) on mechanical (A) and thermal (B) pain behaviors in rats evaluated on day 14 after the inoculation of MRMT-1 tumor cells or PBS. Note that A-803467 remarkably restores the tumor cells-induced reduction of PWT and PWL in cancer model rats but has no significant effect on the PWL and PWT in PBS inoculated sham rats. */# P<0.05, **/## P<0.01, *** P<0.001, compared to vehicle/cancer (MRMT-1) rats group, two-way ANOVA, n = 6–9/group. (C): Inclined-plate test. Note that intrathecal administration of A-803467 at the maximal dose of 150 nmol has no significant effect on the locomotor function of rats. P>0.05, one-way ANOVA, n = 7/group.