Figure 7. Liver damage in GzmB^W/W mice is not the result of immune-mediated pathology.

(A) B6 mice (black bar) or GzmB^W/W mice (white bar) were infected with Δm157 MCMV and total liver leukocytes, inflammatory monocytes, and granulocytes enumerated at the indicated times. Data are pooled from 2 independent experiments, mean ± SEM are plotted, where n≥5. *P<0.05. **P<0.01. (B) Levels of TNF-α and IFN-γ in the liver at the indicated times post-infection were quantified by ELISA. (C) Livers from uninfected or MCMV-infected mice at day 6 post-infection were stained with the Chroma 101 anti-IE1 antibody followed by detection with a DAB substrate. Sections were counterstained with haematoxylin. The results are representative of two independent experiments.