Figure 7. There are fewer CD3+ T cells, but not monocyte/macrophages in lymph node with natalizumab treatment.

(A) There were similar numbers of p28⁺ and SIV RNA⁺ cells in the axillary lymph nodes of all of animals, regardless of treatment or time of sacrifice. (B) Comparable levels of activated resident CD68⁺ macrophages were detected in all macaques. (C) The numbers of MAC387⁺ cells were similar in late and early treated versus non-treated macaques. (D) There was a reduction in CD3⁺ T lymphocytes from tissues of late and early natalizumab treated macaques relative to untreated controls. Each point represents the mean number of positive cells in the three tissue regions examined from a single animal. Lines and error bars indicate the mean ± SEM for each treatment group. Scale bars: 50 microns. P values calculated using unpaired t tests. P≤0.05*, p≤0.01 **.