Figure 1. SOCS1^−/−IFN-γ^−/− mice are more resistant to influenza infection.

(A) Viral titers (6–9 mice/group), (B) albumin levels (4 mice/group), and (C) survival of C57BL/6 WT, IFN-γ^−/−, and SOCS1^−/−IFN-γ^−/− mice after i.n. infection of (A, B) 50 PFU or (C) 10³ PFU PR8 virus. In (A&B), P<0.001, ANOVA; *P<0.05, **, P<0.01, ***, P<0.001, Tukey's multiple comparisons test. Data in (A) were combined from two independent experiments. Data in (B&C) are representative of at least two experiments.