Figure 6. Antiviral immune responses in CD4⁺ T cell depleted mice.

(A) Viral titers (4–6 mice/group), (B) albumin levels (4 mice/group), and (C) H1N1-specific IgM and IgG levels (4–6 mice/group) in C57BL/6 IFN-γ^−/− and SOCS1^−/−IFN-γ^−/− airways after i.n. infection of 50 PFU PR8 influenza virus. Mice were injected i.p. with GK1.5 (anti-CD4) to deplete CD4⁺ T cells. Control mice were treated with rat IgG. In (A), P<0.001, ANOVA; *P<0.05, **, P<0.01, ***, P<0.001, Tukey's multiple comparisons test, the data for each time point were repeated in at least two independent experiments. In (B), *P<0.05, t test. Data in (B&C) are representative of two independent experiments.