FIGURE 4.

Effects of different CaSR activators on duodenal I_sc and DBS in CFTR KO and WT mice. A, time course of duodenal I_sc in wild type mice after addition of spermine (1 mm) or Gd³⁺ (0.5 mm) to Ussing chambers as indicated by the arrow. B, time course of duodenal I_sc in CFTR knockout mice after addition of spermine or Gd³ to Ussing chambers as indicated by the arrow. C, spermine-stimulated net peak DBS in the presence or the absence of U73122 (10 μm) in wild-type mice and in CFTR knockout mice. D, Gd³⁺-stimulated net peak DBS in the presence or the absence of U73122 in wild-type mice and in CFTR knockout mice. Values are expressed as mean ± S.E. for five to six experiments. **, p < 0.01 versus each activator-stimulated net peak DBS in WT mice.