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. 2014 Sep 12;289(50):34871–34885. doi: 10.1074/jbc.M114.571000

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© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 7. — STAT5 and GATA2 restored the angiogenic activity of ECs attenuated by GPR126 knockdown. A, forced expression of STAT5 and/or GATA2 in GPR126 knockdown HMEC-1 cells restored two-dimensional tube formation on Matrigels. pll3.7, control vector of shRNA; Zs, control vector for overexpression; GPR126-Sh, GPR126 shRNA; ST5, STAT5 overexpression; GA2, GATA2 overexpression. B, statistical summary of relative tube length of each group in A. C, restoration of angiogenic activity of endothelial cells in zebrafish embryos. Bright field images showed the morphology of 30 hpf Tg(fli1:EGFP)^y1 zebrafish embryos in each injection treatment. Confocal fluorescence images showed ISVs sprouting of Tg(fli1:EGFP)^y1 embryos of each treatment. D, statistical summary of percentage of embryos with ISV defect in each group in C. The numbers above the column represent the number of embryos with ISV defect/the number of embryos analyzed totally.