Table 3.
Unadjusted and adjusted hazard ratio of clinical outcome by diabetes mellitus status and baseline systolic blood pressure in patients with stage 3 or 4 chronic kidney disease
| Total | Non-DM | DM | ||||
|---|---|---|---|---|---|---|
| Unadjusted HR (95% CI) | Adjusted HRa (95% CI) | Unadjusted HR (95% CI) | Adjusted HRa (95% CI) | Unadjusted HR (95% CI) | Adjusted HRa (95% CI) | |
| CV outcomes SBP, mm Hg | ||||||
| 96–110 | 1.22 (0.67–2.22) | 1.22 (0.67–2.23) | 0.65 (0.24–1.78) | 0.53 (0.19–1.49) | 1.78 (0.81–3.91) | 2.52 (1.13–5.58) |
| 111–120 | Reference group | Reference group | Reference group | Reference group | Reference group | Reference group |
| 121–140 | 1.32 (0.86–2.02) | 1.20 (0.78–1.84) | 1.02 (0.56–1.84) | 1.02 (0.55–1.91) | 1.64 (0.88–3.05) | 1.45 (0.77–2.72) |
| >140 | 1.76 (1.17–2.67) | 1.29 (0.84–1.98) | 1.16 (0.64–2.11) | 1.04 (0.56–1.95) | 2.03 (1.11–3.70) | 1.62 (0.87–3.00) |
| Renal outcomes SBP, mm Hg | ||||||
| 96–110 | 1.01 (0.54–1.91) | 1.41 (0.73–2.74) | 0.99 (0.42–2.34) | 0.65 (0.26–1.64) | 0.99 (0.38–2.55) | 3.14 (1.16–8.49) |
| 111–120 | Reference group | Reference group | Reference group | Reference group | Reference group | Reference group |
| 121–140 | 1.19 (0.77–1.85) | 1.27 (0.80–2.01) | 0.95 (0.52–1.74) | 0.83 (0.43–1.58) | 1.42 (0.74–2.72) | 1.64 (0.82–3.29) |
| >140 | 2.49 (1.64–3.76) | 1.75 (1.13–2.71) | 1.68 (0.95–2.98) | 0.89 (0.48–1.69) | 2.85 (1.54–5.30) | 2.92 (1.51–5.66) |
| All-cause mortality SBP, mm Hg | ||||||
| 96–110 | 1.32 (0.76–2.28) | 1.18 (0.68–2.07) | 1.57 (0.73–3.35) | 1.40 (0.63–3.10) | 1.03 (0.46–2.29) | 1.37 (0.60–3.08) |
| 111–120 | Reference group | Reference group | Reference group | Reference group | Reference group | Reference group |
| 121–140 | 1.13 (0.75–1.71) | 1.15 (0.75–1.74) | 1.34 (0.76–2.38) | 1.58 (0.86–2.91) | 0.90 (0.50–1.62) | 0.85 (0.46–1.55) |
| >140 | 1.42 (0.95–2.11) | 1.25 (0.82–1.90) | 1.59 (0.89–2.82) | 1.60 (0.87–2.94) | 1.12 (0.64–1.95) | 1.03 (0.58–1.86) |
Abbreviations: CI, confidence interval; CV, cardiovascular; DM, diabetes mellitus; HR, hazard ratio; SBP, systolic blood pressure.
aFully adjusted model included age, sex, estimated glomerular filtration rate, urine protein–creatinine ratio, hemoglobin, albumin, phosphorus, total cholesterol, C-reactive protein, body mass index, smoking status, baseline congestive heart failure, myocardial infarction, cerebral vascular disease, and the use of angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, calcium channel blockers, beta-blockers, alpha-blockers, and diuretics.