Table 6.
Adjusted hazard ratios of clinical outcome by diabetes mellitus status and baseline systolic blood pressure in patients with stage 3 or 4 chronic kidney disease taking regular antihypertensive agents
| Total Adjusted HR (95% CI)a | Non-DM Adjusted HR (95% CI)a | DM Adjusted HR (95% CI)a | |
|---|---|---|---|
| Cardiovascular outcomes: SBP, mm Hg | |||
| 96–110 | 2.76 (1.26–6.02) | 0.78 (0.15–4.12) | 5.01 (1.85–13.56) |
| 111–120 | Reference group | Reference group | Reference group |
| 121–140 | 1.82 (0.98–3.38) | 1.27 (0.51–3.19) | 2.28 (0.96–5.38) |
| >140 | 1.93 (1.05–3.55) | 1.31 (0.53–3.24) | 2.34 (1.005–5.46) |
| Renal outcomes: SBP, mm Hg | |||
| 96–110 | 1.69 (0.78–3.67) | 0.70 (0.21–2.32) | 2.85 (0.98–8.30) |
| 111–120 | Reference group | Reference group | Reference group |
| 121–140 | 1.30 (0.76–2.22) | 0.85 (0.39–1.87) | 1.49 (0.71–3.12) |
| >140 | 1.84 (1.11–3.04) | 0.86 (0.40–1.89) | 2.60 (1.29–5.26) |
| All-cause mortality: SBP, mm Hg | |||
| 96–110 | 1.84 (0.73–4.59) | 2.87 (0.78–10.62) | 1.40 (0.37–5.35) |
| 111–120 | Reference group | Reference group | Reference group |
| 121–140 | 1.65 (0.83–3.27) | 1.87 (0.71–4.94) | 1.41 (0.52–3.80) |
| >140 | 1.89 (0.96–3.71) | 2.12 (0.81–5.54) | 1.75 (0.66–4.61) |
Abbreviations: CI, confidence interval; DM, diabetes mellitus; HR, hazard ratio; SBP, systolic blood pressure.
aFully adjusted model included age, sex, estimated glomerular filtration rate, urine protein–creatinine ratio, hemoglobin, albumin, phosphorus, total cholesterol, C-reactive protein, body mass index, smoking status, baseline congestive heart failure, myocardial infarction, cerebral vascular disease, and the use of angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, calcium channel blockers, beta-blockers, alpha-blockers, and diuretics.