Table 2.
Association of variants in epithelial sodium channel genes with blood pressure changes among Genetic Epidemiology Network of Salt Sensitivity participants
| Gene | SNP | Chr | Position | Genotype | SBP | DBP | ||
|---|---|---|---|---|---|---|---|---|
| β (SE) | P interaction value | β (SE) | P interaction value | |||||
| SCNN1A | rs11064153 | 12 | 6488450 | C/C (n = 242) | 1.49 (0.12) | 5.8×10 –4 | 1.00 (0.10) | 0.02 |
| T/C (n = 776) | 1.44 (0.08) | 0.98 (0.06) | ||||||
| T/T (n = 757) | 1.14 (0.07) | 0.82 (0.05) | ||||||
| SCNN1G | rs4401050 | 16 | 23217402 | T/T (n = 28) | 1.64 (0.42) | 0.001 | 1.28 (0.25) | 0.005 |
| C/T (n = 435) | 1.48 (0.12) | 0.89 (0.08) | ||||||
| C/C (n = 2090) | 1.16 (0.06) | 0.77 (0.04) | ||||||
Position was GRCh37.p8. β indicates the average change in BP per year according to genotypes. P interaction is for genotype by follow-up time interactions. P values in boldface indicate statistical significance after Bonferroni correction (0.05/43 = 0.001).
Abbreviations: BP, blood pressure; Chr, chromosome; DBP, diastolic blood pressure; SBP, systolic blood pressure; SNP, single nucleotide polymorphism.