Table 3.
Association of variants in epithelial sodium channel genes with hypertension incidence among Genetic Epidemiology Network of Salt Sensitivity participants
| Gene | SNP | Chr | Position | Maj/Min | MAF | Hypertension incidence | |
|---|---|---|---|---|---|---|---|
| RR (95% CI) | P value | ||||||
| SCNN1A | rs11064153 | 12 | 6488450 | T/C | 0.36 | 1.23 (1.04–1.46) | 0.02 |
| SCNN1G | rs4401050 | 16 | 23217402 | C/T | 0.10 | 1.13 (0.90–1.42) | 0.29 |
Abbreviations: Chr, chromosome; CI, confidence interval; MAF, minor allele frequency; Maj/Min, major allele/minor allele; Position, GRCh37.p8; RR, relative risk: increased risk of hypertension incidence as per minor allele increase; SNP, single nucleotide polymorphism.