Table 1.

Patient, donor, and allograft characteristics

Characteristic	AML patients (n = 138)		MDS patients (n = 28)		ALL patients (n = 43)		Entire cohort (n = 209)
	No.	%	No.	%	No.	%	No.	%
Age at BMT, years
Median	51		55.5		47		50
Range	20-66		28-63		18-61		18-66
Female patients	72	52	18	64	24	56	114	55
HCT-CI
Median	2		3		1		2
Range	0-12		0-8		0-5		0-12
HCT-CI
0	25	18	3	11	16	37	44	21
1-2	50	36	9	32	16	37	75	36
≥3	63	46	16	57	11	26	90	43
Pretransplant remission status
CR without MRD	76	55	1	4	31	72	108	52
CR with MRD	25	18	1	4	12	28	38	18
Active disease	37	27	26	93	0	0	63	30
Conditioning
Bu/Cy	120	87	23	82	29	67	172	82
Bu/Flu	18	13	5	18	13	30	36	17
Cy/TBI	0	0	0	0	1	2	1	0.5
Graft source
Bone marrow	137	99.3	28	100	43	100	208	99.5
Peripheral blood	1	0.7	0	0	0	0	1	0.5
Donor
Matched-related	78	57	14	50	24	56	116	56
Matched-unrelated	60	43	14	50	19	44	93	44
Donor age, years
Median	44		48.5		41		43
Range	17-75		21-66		21-62		17-75
Female donors	66	48	14	50	16	37	96	46
Female-into-male allografting	26	19	4	14	4	9	34	16
CMV serostatus
Patient positive	79	57	12	43	19	44	110	53
Donor positive	53	38	7	25	15	35	75	36
Graft cell counts*
Nucleated cells × 108
Median	4.04		4.29		3.90		4.06
Range	0.99-8.07		0.95-8.82		0.88-7.02		0.88-8.82
CD34+ cells × 106
Median	3.35		3.34		3.78		3.45
Range	0.97-8.36		1.52-9.87		1.63-8.17		0.97-9.87
CD3+ cells × 107
Median	3.70		3.92		3.73		3.73
Range	0.60-8.28		1.95-9.32		2.37-9.59		0.60-9.59
CD4+ cells × 107
Median	2.08		2.06		1.77		2.03
Range	0.37-9.90		0.95-5.00		1.10-5.25		0.37-9.90
CD8+ cells × 107
Median	1.58		1.45		1.62		1.58
Range	0.48-22.4		0.70-3.60		0.97-4.01		0.48-22.4

BMT, blood or marrow transplantation; Flu, fludarabine, TBI, total body irradiation.

^*Cell counts shown are for the 208 patients treated with bone marrow allografts. Nucleated, CD34⁺, and CD3⁺ cell counts were available for all patients. The CD4⁺ and CD8⁺ cell counts shown reflect available data from 139 patients (67%).