. 2014 Sep 16;3(9):813–822. doi: 10.1016/j.molmet.2014.09.004

Table 1.

Effect of global and conditional transcription factor knockout models on ARC neurons.

Gene	Type	Model	Effect on POMC neurons	Effect on NPY/AgRP neurons	Ref
Rax	Homeobox transcription factor	Six3::Cre;Rax^flox/null	x		[10]
Bmpr1a	Receptor	Olig1^cre/+BMPR1a^fx/−	−	+	[14]
Ngn3	bHLH transcription factor	Ngn^−/−	−	+	[18,17]
Ngn3	bHLH transcription factor	Nkx2.1iCre/+;Ngn3^flox/flox	−	=	[19]
Nhlh2	bHLH transcription factor	Nhlh2^−/−	=	−	[22,24,25]
Nhlh2	bHLH transcription factor	POMC EGFP/GnRH Cre/NSCL-2^{ΔloxP/ΔloxP}	−		[27]
Mash1	bHLH transcription factor	Mash1^−/−	−	−	[28]
Mash1	bHLH transcription factor	Mash1^+/−	=	+	[28]
Rbpjκ	Notch cofactor	Rbpjκ^fl/fl Nkx2.1-^cre+/cre	+	+	[29]
Notch1	Receptor	Rosa^NotchICD/+ Nkx2.1^cre+/cre	x	x	[29]

x — Absent/ablated; + Increased; − Decreased; = No change.