Peripheral exendin-4 decreases plasma TG, cholesterol and apoB100 accumulation. Following the intervention (A–C) or preventative (D–F) study, hamsters were fasted for 5 h and received an intraperitoneal (ip) injection of vehicle or exendin-4 (20 μg/kg) followed by an ip injection of poloxamer (0.5 g/kg). (A,D) Plasma triglyceride, (B,E) cholesterol, (C,F) and apoB100 accumulation. Intervention n = 5–7; Preventative n = 6; *p < 0.05, **p < 0.01, ***p < 0.001 as analyzed by two-way ANOVA with Bonferroni post hoc test.