Peripheral exendin-4 decreases VLDL associated-TG, -cholesterol and apoB100 accumulation. VLDL isolated from vehicle or exendin-4 hamsters in the intervention (A–C) or preventative (D–F) study. (A,D) VLDL-triglyceride, (B,E) cholesterol, (C,F) and apoB100 accumulation with area under the curve (AUC) for VLDL-apoB100 (C). Intervention n = 5–7; Preventative n = 6; *p < 0.05, **p < 0.01, ***p < 0.001 as analyzed by two-way ANOVA with Bonferroni post hoc test. AUC analyzed by Mann–Whitney U test.