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. 2014 Sep 28;3(9):823–833. doi: 10.1016/j.molmet.2014.09.005

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© 2014 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).

PMC Copyright notice

Exendin-4 requires vagal signaling to reduce fasting dyslipidemia. Hamsters underwent a subdiaphragmatic truncal vagotomy/sham surgery and allowed 1 week recovery followed by the intervention study. (A) Total weight loss (B) Changes in food consumption on fructose (week 2) and during treatment (week 3). (C) Changes in fasted plasma TG and (D) cholesterol levels before (Day 0) and after the study (Day 21). (E,F) Changes in VLDL-TG and VLDL-cholesterol up to 2 h posttriton. n = 3. *p < 0.05, **p < 0.01, ***p < 0.001. Analyzed by one way (A) or two-way ANOVA (B–F) with Bonferroni post hoc test.