Figure 1.

Effect of homocysteine on neointima formation and adventitial hyperplasia of balloon injured arteries. (HE, hematoxylin and eosin stain ×50).The neointimal areas in control group were smaller than that in hyperhomocysteinemia (HHcy) group at day 28 after balloon injury ((A) control group, (B) HHcy group); Adventitial hyperplasia in control group was observed at 7 days of balloon injury (C); Adventitial hyperplasia in HHcy group futher increased at the same time point (D); and (E–H)Effect of homocysteine on luminal area, neointimalarea adventitial changes in the normal artery (non-injured carotid artery) and injured arteries. Scale bars = 100 μm. ^Δ p < 0.05, ^ΔΔ p < 0.01 versus normal artery with control diet; ^# p < 0.05, ^## p < 0.01 versus normal artery with l-methionine-induced HHcy group; * p < 0.05, ** p < 0.01 versus control group of the same time point.