Table 2.

Distribution of genotypes and alleles of the g.46438521G>C—NEIL1, c.2285T>C—PARP-1, c.–1370T>A—POLG, c.580C>T—XRCC1 and c.1196A>G—XRCC1 polymorphisms and odds ratio (OR) with 95% confidence interval (95% CI) in patients with KC and controls.

Polymorphism Genotype/Allele	Controls (n = 353)				KC (n = 284)				Crude OR (95% CI)	p		Adjusted OR a (95% CI)		p
	Number		Frequency		Number		Frequency
g.46438521G>C—NEIL1
C/C	98		0.28		77		0.27		0.97 (0.68–1.37)	0.855		0.65 (0.39–1.09)		0.104
C/G	240		0.68		188		0.66		0.92 (0.66–1.29)	0.632		1.37 (0.84–2.24)		0.210
G/G	15		0.04		19		0.07		1.61 (0.81–3.24)	0.177		1.42 (0.49–4.14)		0.518
χ2 = 1.856; p = 0.3953
C	436		0.62		342		0.60		0.89 (0.67–1.20)	0.463		0.69 (0.44–1.07)		0.099
G	270		0.38		226		0.40		1.12 (0.83–1.50)	0.463		1.45 (0.93–2.25)		0.099
c.2285T>C—PARP-1
A/A	239		0.68		191		0.67		0.98 (0.70–1.37)	0.904		0.95 (0.59–1.53)		0.825
A/G	114		0.32		93		0.33		1.02 (0.73–1.42)	0.904		1.05 (0.65–1.70)		0.825
G/G	0		0		0		0		–	–		–		–
χ2 = 0.001; p = 0.9713
A	592		0.84		475		0.84		0.98 (0.70–1.37)	0.904		0.95 (0.59–1.53)		0.825
G	114		0.16		93		0.16		1.02 (0.73–1.42)	0.904		1.05 (0.65–1.70)		0.825
c.–1370T>A—POLG
A/A	46		0.13		62		0.22		1.86 (1.23–2.83)	0.004		2.71 (1.44–5.08)		0.002
A/T	203		0.57		139		0.49		0.71 (0.52–0.97)	0.031		0.35 (0.22–0.56)		0.002
T/T	104		0.30		83		0.29		0.99 (0.70–1.39)	0.948		1.27 (0.77–1.58)		0.358
χ2 = 9.341; p = 0.0094
A	295		0.42		263		0.46		1.22 (0.97–1.55)	0.091		1.22 (0.87–1.72)		0.250
T	411		0.58		305		0.54		0.82 (0.65–1.03)	0.091		0.82 (0.58–1.15)		0.250

^a OR adjusted for sex, age, co-occurrence of visual impairment, allergies, and family history for KC.