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. 2014 Oct 29;15(11):19700–19728. doi: 10.3390/ijms151119700

Figure 4.

Figure 4

GPCR-mediated TβRI transactivation. Stimulation of protease activated receptor 1 (PAR1) with thrombin induces the activation of Rho/ROCK which, in turn, triggers integrin-mediated TGF-β activation. The activated ligand binds to TβRI promoting the phosphorylation of Smad2 and the formation of pSmad activated complexes.