Table 3.
RTKs transactivation: role of tyrosine kinases.
| Cell Lines | Stimulus | GPCR | Tyrosine Kinases | RTK | Biological Responses | Ref. |
|---|---|---|---|---|---|---|
| PC3 | Neurotensin | NTRs | c-Src | EGFR | EGFR transactivation, cell proliferation, DNA synthesis, STAT5-b activation | [83] |
| COS-7 | α2-AR agonists | α2-AR | c-Src | EGFR | EGFR transactivation, ERK activation | [85] |
| C9 | Ang II | AT1 | c-Src/Pyk2 | EGFR | EGFR transactivation, ERKs phosphorilation | [86] |
| HEK293 | AVP | V2R | c-Src | IGFR | IGFR transactivation, ERKs activation | [87] |
| PC12-615 | Adenosine, GCS21680 | Adenosine receptor | Fyn | TrkA | TrkA transactivation. | [91] |
| SH-SY5Y | 5-HT | 5-HT1A | c-Src | PDGFR-β | PDGFR-β transactivation | [92] |
| COS-7 | Isoproterenol | β2AR | c-Src | EGFR | EGFR transactivation, ERKs activation | [97] |
| Gastric mucosal cells | Isoproterenol | β2-AR | c-Src | EGFR | EGFR transactivation and regulation of gastric mucin secretion | [98] |
| Cardiomyocytes | Endothelin-1 | ET-1 | Pyk2 | EGFR | EGFR transactivation, MAPK activation | [103] |
5-HT, Serotonin; 5-HT1A, Serotonin receptor; Ang II, Angiotensin II; AT1, Angiotensin II receptor type 1; AVP, Vasopressin; C9, Rat hepatic cells; COS-7, Fibroblast-like cell line; EGFR, Epidermal growth factor receptor; ET-1, Endothelin receptor; HEK293, Human embryonic kidney 293 cells; IGFR, Insulin-like growth factor 1 receptor; NTSR, Neurotensin receptor; PC12-615, Rat pheochromocytoma cell line; PC3, Human prostate carcinoma cells; PDGFR-β, Platelet-derived growth factor receptor; SH-SY5Y, Human neuronal cells; TrkA, Neutrophic tyrosine kinase receptor type 1; V2R, Vasopressin receptor; VSMCs, Vascular smooth muscle cells; β2AR, β2-Adrenergic receptors.