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. 2014 Oct 31;15(11):19816–19831. doi: 10.3390/ijms151119816

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© 2014 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).

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PTH/PTHrP can affect Hh signaling pathway downstream gene expression. (A) Treatment with recombinant PTH (10 nM) alone did not alter the expression of Hh pathway-related genes PTCH1, GLI1, and IFT88 significantly (p > 0.05); (B) After inducing cilia by serum-free medium, Hh pathway was activated and PTH could suppress target genes expression significantly (p < 0.001); (C) Treatment with chloral hydrate down-regulated target genes to a certain extent, and PTH could not distinctively change the trend (p > 0.05). Three independent assays were conducted. (* p < 0.05).