Table 2.
Diagnostic values of DcR3 and CSF markers for the diagnosis of bacterial meningitis.
| Variable | Cut-off Value | Sensitivity (%) | Specificity (%) | PLR | NLR | PPV (%) | NPV (%) |
|---|---|---|---|---|---|---|---|
| Leucocyte count | 116 (×106/L) | 88.75 (79.24–94.41) | 90.70 (76.95–96.98) | 9.54 (3.74–24.34) | 0.12 (0.07–0.23) | 94.67 (86.19–98.28) | 81.25 (66.90–90.56) |
| Glucose | 2.14 (mmol/L) | 65.00 (53.44–75.10) | 67.44 (51.34–80.46) | 2.00 (1.26–3.16) | 0.52 (0.38–0.72) | 78.79 (66.66–87.52) | 50.88 (37.44–64.20) |
| Protein | 1.14 (g/L) | 43.75 (32.83–55.27) | 86.05 (71.37–94.20) | 3.14 (1.43–6.86) | 0.65 (0.53–0.80) | 85.37 (70.14–93.91) | 45.12 (34.24–56.46) |
| Lactate | 2.64 (mmol/L) | 62.50 (50.92–72.87) | 74.42 (58.53–85.96) | 2.44 (1.43–4.18) | 0.50 (0.37–0.68) | 81.97 (69.60–90.24) | 51.61 (38.68–64.34) |
| DcR3 | 0.201 (ng/mL) | 78.75 (67.89–86.79) | 81.40 (66.08–91.08) | 4.23 (2.24–7.99) | 0.26 (0.17–0.40) | 88.73 (78.47–94.66) | 67.31 (52.78–79.28) |
All parameters except cut-off value are presented with 95% confidence intervals. The Youden Index determines cut-off point. PLR: positive likelihood ratio; NLR: negative likelihood ratio; PPV: positive predictive value; NPV: negative predictive value.