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. 2014 Nov 6;15(11):20339–20354. doi: 10.3390/ijms151120339

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© 2014 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).

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Schematic diagram and XPS analysis of Ch₂-PEG_n-CLs. (A) Ch segments of Ch₂-PEG_n anchored into the lipid bilayer of CLs. Due to the short PEG chain, Ch₂-PEG₆₀₀ did not effectively shield the charge of CLs. Ch₂-PEG₁₀₀₀ and Ch₂-PEG₂₀₀₀ decreased the positive charge by covering the surface of CLs. With longer PEG chains, Ch₂-PEG₂₀₀₀ compressed the liposomal particle and therefore Ch₂-PEG₂₀₀₀-CLs showed a smaller particle size; (B) XPS analysis demonstrated that more PEG segments were located on the surface of liposomes when PEG molecular weight increased.