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(a) Caspase 3/7 activity after sorafenib treatment with different concentrations for 24 h compared to untreated controls (co: control, set as 1). A significant increase in caspase 3/7 activity was noted in both T24 and VMCub1 cells at a concentration of 20 µM. (Bonferroni’s posttest, *** p < 0.001, ns: not significant); and (b) Changes in cell cycle distribution and amount of apoptotic cells (as sub-G1 fraction) after sorafenib treatment (2 and 10 µM, 48 and 72 h).
