Table 1.
Compositions of the molecularly imprinted polymers prepared with methacrylic acid (MAA) (in mmol) a. MIP, molecularly-imprinted polymer; EGDMA, ethylene glycol dimethacrylate; AIBN, 2,2'-azobis-(2-methylpropionitrile).
| Polymer | Bupivacaine | MAA | EGDMA | AIBN | Toluene | Molar Ratio b |
|---|---|---|---|---|---|---|
| MIP 0 | 1.39 | 0.00 | 77.4 | 2.00 | 219.8 | 1:0:56 |
| MIP 1 | 1.39 | 3.30 | 78.1 | 2.10 | 226.0 | 1:2:56 |
| MIP 2 | 1.39 | 7.23 | 74.5 | 2.03 | 221.5 | 1:5:54 |
| MIP 3 | 1.39 | 12.51 | 77.4 | 2.18 | 236.4 | 1:9:56 |
| MIP 4 | 1.39 | 16.68 | 77.4 | 2.23 | 240.9 | 1:12:56 |
| MIP 5 | 1.39 | 20.1 | 82.3 | 2.40 | 259.4 | 1:14:59 |
| MIP 6 | 1.39 | 22.24 | 77.4 | 2.30 | 246.9 | 1:16:56 |
| MIP 7 | 1.39 | 25.02 | 77.4 | 2.30 | 251.4 | 1:18:56 |
| MIP 8 | 1.39 | 30.90 | 82.6 | 2.55 | 274.0 | 1:22:59 |
| MIP 9 | 1.39 | 64.20 | 76.2 | 2.80 | 298.4 | 1:46:55 |
a Non-imprinted reference polymers were also prepared, though in the absence of bupivacaine. b Bupivacaine:MAA:EGDMA.