Table 1.

MicroRNAs (miRNAs) involved in medulloblastoma (MB) biology as oncogenes or tumor suppressors.

miRNAs (miRs)	Targets	References
Oncomirs
miR-21	PDCD4	[78]
miR-517c, miR-520g	miR-517c WNT/JNK signaling, miR-520g ABCG2	[79,80]
miR-221, miR-222	p27Kip1	[6]
miR-183-96–182 cluster	Undefined, however knockdown of the full miR-183-96–182 cluster results in enrichment of genes associated with apoptosis and dysregulation of the PI3K/AKT/mTOR signaling axis	[68]
miR-17/92	TSP-1, Bmi-1, PTEN, PP2A	[63,81,82]
miR-214	Gli1	[4]
miR-30b, miR-30d	Undefined, Both miRNAs are part of an amplicon containing the KHDRBS3 gene on 8q24.22 in MB cell lines	[83]
miR-106b	p21	[69,84]
Tumor Suppressors miRNAs
miR-125a	t-TrkC	[69]
miR-9	REST/NRSF, Hes1	[39,69]
miR-125b, miR-324-5p, miR-326	PKM2, SMO, Notch	[4,85]
let-7	RAS, STAT3	[69,86]
miR-199b-5p	HES1, Notch pathway, ErbB2	[87]
miR-124a	CDK6, SLC16A1, REST, BAF34a, RB1,t-TrkC	[35,58,60,88,89]
miR-218	EGFR, Bcl-2, B-catenin and MAPK9	[84,90]
miR-31, miR-153	miR-153 is found in high ErbB2 expressing MB	[69,90]
miR-128a, miR-128b, miR-181b	Bmi-1	[64,91]
let-7 miRNA family	HMGA2	[7]