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. 2014 Nov 25;11:60. doi: 10.1186/s12989-014-0060-6

Table 5.

Association between inorganic soluble chemical constituents, polyaromatic hydrocarbons (PAHs) and microbes in different seasons and the inflammatory and cytotoxic response markers in mouse macrophages after exposure to three different doses of particles (50, 150 and 300 μg/ml) for 24 h

Winter Spring
n MTT PI SubG 1 TNFα MIP2 n MTT PI SubG 1 TNFα MIP2
PC1 Al 12 0.273 0.07 0.154 0.126 0.245 12 .692* 0.503 −0.049 .951** .937**
Ca 12 0.49 0.385 0.231 0.147 0.287 12 .860** .769** 0.315 .909** .937**
Fe 9 0.383 0.017 −0.183 0.633 0.533 12 .713** 0.517 −0.028 .888** .860**
K 12 .601* .720** .671* 0.035 0 12 .881** .776** 0.252 .825** .825**
Mg 12 0.161 0.091 0.105 −0.175 −0.014 12 .818** .720** 0.196 .916** .930**
Na 12 0.378 0.329 0.336 −0.035 0.084 12 .853** .748** 0.189 .832** .818**
Ni 12 0.053 0.256 0.572 −0.509 −0.484 12 .911** .795** 0.385 .725** .736**
PC2 SO4 12 0.28 0.538 .818** −0.315 −0.392 12 0.014 0.105 0.224 −0.524 −0.538
NO3 12 0.035 −0.049 0.203 −0.14 −0.028 12 .650* 0.545 0.147 0.42 0.378
V 12 .587* .699* .727** 0.098 0.063 12 .755** .678* 0.196 .587* 0.566
Zn 12 0.252 0.399 0.552 −0.329 −0.294 12 .881** .797** 0.538 .622* .664*
TotalPAH 12 −0.063 0.098 0.483 −0.517 −0.455 12 0.112 0.147 0.315 −0.483 −0.49
PC3 Cl 12 .720** 0.434 0.035 .783** .853** 12 .820** .753** 0.305 .893** .918**
F 9 .933** .917** .717* .683* 0.6 9 .733* 0.633 .750* 0.183 0.3
Cu 12 0.2 0.273 0.375 −0.319 −0.228 12 .846** .811** 0.42 .797** .825**
PC4 Universal bacterial assay 12 .776** .692* 0.147 .608* .594* 12 .909** .769** 0.315 .874** .888**
Other Genotoxic PAH 12 −0.084 0.14 0.566 .-580* −0.545 12 0.112 0.147 0.315 −0.483 −0.49
EUPah 12 −0.105 0.154 .615* .-636* .-622* 12 0.046 0.091 0.368 .-602* .-592*
Penicillium sp./Aspergillus sp. 12 .818** .713** 0.161 .650* .657* 12 .706* .664* .594* .676* .655*
Cladosporidium cladosprioides 9 .850** .917** .767* 0.3 0.283 12 .708* 0.508 0.077 .676* .655*
Streptomyces sp. 6 .943** .943** 0.771 .829* .829* 12 0.406 0.455 0.538 −0.105 −0.056
Mycobacterium sp. 9 .817** .900** .750* 0.233 0.183 12 .783** .692* 0.259 .944** .965**
Summer Autumn
n MIT PI SubG1 TNFa MIP2 n MIT PI SubG1 TNFa MIP2
PC1 A 12 .805** .851** 0.341 .886** .939** 12 .636* .678* 0.301 .958** .951**
Ca 12 .755** .846** 0.49 .748** .832** 12 .804** .825** .741** .678* .720**
Fe 12 .692* .755** 0.287 .832** .888** 12 0.462 .594* 0.175 .888** .881**
K 12 .587* .731** 0.476 0.517 .629* 12 0.573 .671* 0.552 .622* .650*
Mg 12 .881** .937** .615* .720** .797** 12 .853** .867** .601* .916** .944**
Na 12 .881** .916** .741** .580* .657* 12 .734** .797** .594* .804** .832**
Ni 12 .587* .720** 0.538 0.448 0.573 12 0.442 0.495 0.495 0.431 0.452
PC2 SO4 12 −0.168 −0.007 0.469 −0.503 −0.378 12 0.119 0.105 0.559 −0.469 −0.413
NO3 12 0.462 0.559 .650* 0.119 0.203 9 0.45 .733* 0.383 .667* .750*
V 12 0.399 0.559 0.448 0.301 0.448 12 0.52 .671* .608* 0.485 0.527
Zn 12 0.231 0.413 0.517 0.014 0.168 12 0.545 .587* .790** 0.126 0.196
TotalPAH 12 0.186 0.34 .669* −0.224 −0.095 12 −0.021 0.112 0.455 −0.441 −0.378
PC3 C1 12 .811** .846** .615* .601* .657* 12 .762** .825** 0.573 .867** .895**
F 12 .797** .832** .881** 0.308 0.371 9 .750* .733* 0.633 .733* .783*
Cu 12 0.462 .594* .769** 0.091 0.238 12 .818** .769** .741** .643* .678*
PC4 Universal bacterial assay 12 .916** .846** 0.28 .944** .923** 12 .958** .818** .783** .650* .692*
Other GenoPAH 12 0.042 0.203 0.545 −0.308 −0.175 12 −0.056 0.056 0.427 −0.503 −0.441
EUPah 12 −0.278 −0.091 0.344 −0.499 −0.359 12 −0.112 −0.021 0.378 −0.573 −0.51
Penicillium sp./Aspergillus sp. 12 .916** .846** 0.28 .944** .923** 12 0.545 .713** 0.517 .643* .678*
Cladosporidium cladosprioides 12 .916** .846** 0.28 .944** .923** 12 0.573 .713** 0.301 .909** .923**
Streptomyces sp. 12 .797** .846** .748** 0.469 0.552 9 .867** .983** .800** 0.533 0.65
Mycobacterium sp. 9 .900** .883** 0.25 .967** .967 9 .733* .917** 0.567 .817** .883**

The values are Spearman correlation coefficients (ρ), (** p < 0.01, * p < 0.05).

Genotoxic PAH compounds according to WHO (1998).

EU PAH compounds according to the EU Directive 2004/107/EC.