Table 2.
Pathogenicity of the SW/3/06 virus in different mammalian species
| Species (inoculation route) | Mortality a | MDT (days) | Dose (EID 50 ) b | Antibody titer on indicated day post-infection c | ||
|---|---|---|---|---|---|---|
| 14 | 21 | 28 | ||||
| BALB/c mice (i.n.) | 5/5 | 2.4 | 104.0 | ND | ND | ND |
| BALB/c mice (i.m.) | 5/5 | 2.8 | 104.0 | ND | ND | ND |
| Guinea pigs (i.n.) | 0/5 | >14.0 | 104.3 | 5.0 ± 1.0 | 5.3 ± 0.6 | 5.7 ± 0.6 |
| Guinea pigs (i.m.) | 0/5 | >14.0 | 104.3 | 4.7 ± 1.1 | 4.7 ± 0.6 | 5.3 ± 0.6 |
| Guinea pigs (i.n.) | 0/3 | >14.0 | 106.0 | 5.0 ± 0.0 | 5.7 ± 0.6 | 6.0 ± 0.0 |
| Guinea pigs (contact) | 0/3 | >14.0 | – | < 1.0 | < 1.0 | < 1.0 |
| Large White pigs (i.n.) | 0/5 | >14.0 | 105.3 | 3.7 ± 0.6 | 4.0 ± 0.0 | 4.7 ± 0.6 |
| Large White pigs (i.m.) | 0/5 | >14.0 | 105.3 | 3.0 ± 0.0 | 3.3 ± 0.6 | 4.0 ± 0.0 |
| Scottish Fold cats (i.n.) | 0/3 | >14.0 | 104.6 | 7.0 ± 1.0 | 8.3 ± 1.1 | 8.7 ± 0.6 |
| Scottish Fold cats (i.t.) | 0/3 | >14.0 | 104.6 | 7.0 ± 1.7 | 8.0 ± 0.0 | 8.3 ± 0.6 |
| Beagle dogs (i.n.) | 3/3 | 2.3 | 104.6 | ND | ND | ND |
| Beagle dogs (i.t.) | 3/3 | 4.7 | 104.6 | ND | ND | ND |
aNumber of mammals that died/number of mammals inoculated.
bDetermined by back titer determination of the inoculum; EID50, 50% egg infectious dose.
cPresented as Log2 HI titer ± standard deviation. Antibody titers were determined by an HI assay of two-fold diluted serum.
ND, not determined.