Skip to main content
. Author manuscript; available in PMC: 2014 Dec 12.
Published in final edited form as: Circ Res. 2011 Nov 17;110(2):295–303. doi: 10.1161/CIRCRESAHA.111.259242

Table 2.

Differential sGC responsiveness within microdomains of normal and hypertrophied hearts

Relative Response Cav3+LR NLR
Sham TAC Sham TAC
BAY 60-2770: DEA/NO 1.0 0.6 3.5 17.4

Relative response ratios were calculated using the % change in cGMP levels within respective microdomains of Sham and TAC hearts. Values are normalized to the response ratio of Sham Cav3+LR fraction. Increasing BAY 60-2770:DEA/NO ratios reflect enhanced response to BAY 60-2770 and diminished response to DEA/NO, resulting from heme-oxidization of sGC.