Figure 9.

Proposed model for inhibition of EGF-induced EGFR function by AnxA2 antibody in triple-negative and Herceptin-resistant breast cancer. AnxA2 and EGFR recruitment at cell surface is important for EGFR function that regulates cell proliferation and migration. Blocking AnxA2 function at the cell surface inhibits the EGF-induced EGFR homodimerisation, tyrosine phosphorylation, internalisation and EGFR-mediated downstream AKT and ERK signalling pathways resulting in inhibition of cell proliferation and migration in triple-negative and Herceptin-resistant breast cancer cells.