Skip to main content
. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: J Pain. 2014 May 2;15(7):771–777. doi: 10.1016/j.jpain.2014.04.005

Figure 2. Effect of dipyridamole, nicardipine and CFTRinh-172 (ABC transport inhibitors) on ET-1 induced mechanical hyperalgesia and SDH.

Figure 2

15 min before ET-1, rats received vehicle (5 μl), dipyridamole, nicardipine or CFTRinh-172 (all 1 μg in 5 μl/paw). Paw withdrawal thresholds were measured 15, 20, 25 & 30 min after ET-1 administration. Neither dipyridamole, nicardipine nor CFTRinh-172 affected ET-1 SDH (P=N.S., two-way repeated measures ANOVA, N = 6), however CFTRinh-172 significantly attenuated ET-1 hyperalgesia (2-way ANOVA with Dunnet’s post hoc test, *P<0.05). Note that the ET-1 alone data is the same group as in Figure 1.