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(a) Histologic examination of the biopsy specimen reveals predominantly monotonous polygonal shaped cells with prominent nucleoli and cytoplasm ranging from clear to eosinophilic. Immunohistochemical stains for (b) OCT 3/4 and (c) CD117 reveal strong reactivity. CD117 marker may also be found in other tumors such as gastrointestinal stromal tumors, whereas OCT 4 is relatively specific for germ cells. When CD117 and OCT 4 are used together, they are quite specific for a germinoma.
